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TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1)

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FLN29

TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1)
CCC M394
HGNC 24808
MGI 1923551
PubMed 12477932
RGD 620171
UniProt O14545
Wiki TRAFD1
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses.The deduced human and mouse proteins contain 582 and 576 amino acids, respectively. TRAFD1 has an N-terminal RING finger domain, followed by a zinc finger domain, and TRAF-N and TRAF-C domains. Northern blot analysis of mouse tissues showed expression skeletal muscle, brain, kidney, spleen, and bone marrow.FLN29 is activated by STAT1 and functions as a negative feedback regulator of TLR signaling downstream of TRAF6.Small interfering RNA-induced downregulation of Fln29 reversed these effects and increased the production of nitrous oxide. Fln29 inhibited Toll-like receptor (TLR) signaling by interacting directly with Traf6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1) ELISA Kit Customized Service Offer
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  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the ZF-TRAF domain of FLN29 gene product."Submitted (JUN-2006) to the PDB data bank