Transformer 2 Beta (TRA2b)
[Edit]SRFS10; Htra2-beta; TRA2-BETA; TRA2B; Splicing Factor,Arginine/Serine-Rich 10; Transformer-2 protein homolog B
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TRA2-beta gene contains 10 exons and spans 21 kb. RT-PCR and analysis of TRA2-beta cDNAs in the EST database indicated that 5 different TRA2-beta RNA isoforms are generated by alternative splicing.
TRA2-beta-1 is a nuclear protein that colocalizes with SC35 in a speckled pattern. It interacts with several SR proteins in yeast. A second isoform, named TRA2-beta-2, is generated by alternative splicing. This isoform gives rise to a truncated protein without an SR domain. Both isoforms are evenly distributed throughout adult rat tissue. The ratio of these 2 isoforms changes after stimulation of primary human T-cell and primary rat spleen cell cultures, indicating that alternative splicing is involved in the regulation of TRA2-beta activity.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPM389Hu01 | Recombinant Transformer 2 Beta (TRA2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPM389Hu02 | Recombinant Transformer 2 Beta (TRA2b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAM389Hu01 | Polyclonal Antibody to Transformer 2 Beta (TRA2b) | WB; IHC; ICC; IP. |
| Assay Kits | SEM389Hu | ELISA Kit for Transformer 2 Beta (TRA2b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transformer 2 Beta (TRA2b) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transformer 2 Beta (TRA2b) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transformer 2 Beta (TRA2b) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transformer 2 Beta (TRA2b) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transformer 2 Beta (TRA2b) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transformer 2 Beta (TRA2b) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transformer 2 Beta (TRA2b) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transformer 2 Beta (TRA2b) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transformer 2 Beta (TRA2b) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transformer 2 Beta (TRA2b) | ELISA Kit Customized Service Offer |
- "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing."DNA Cell Biol. 16:679-690(1997) [PubMed] [Europe PMC] [Abstract]
- "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform."Genomics 53:191-202(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]