≡

Transducin Like Enhancer Of Split 2 (TLE2)

[Edit]

ESG; ESG2; GRG2; Enhancer Of Split Groucho 2

Transducin Like Enhancer Of Split 2 (TLE2)
CCC M372
HGNC 11838
MGI 104635
PubMed 8808280
RGD 1306665
UniProt Q04725
Wiki TLE2
The TLE genes are human homologs of the Drosophila 'groucho' gene and their products belong to this pathway. Analysis of mutant alleles of members of the Notch cascade showed that Notch signaling extends the differentiation-competent state of developmentally immature precursor cells, thereby preventing or delaying their differentiation until the correct morphogenetic signals become available . A number of pathologies resulting from incomplete cellular differentiation due to this general inhibitory action during cell determination were shown to be the result of alterations in Notch signaling, including both lymphoblastic and epithelial neoplasms. TLE1 , TLE2, and TLE3 are coexpressed in a number of epithelial tissues. Moreover, they showed that the expression is elevated in cervical squamous metaplasias and carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 2 (TLE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 2 (TLE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 2 (TLE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 2 (TLE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 2 (TLE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 2 (TLE2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 2 (TLE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 2 (TLE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 2 (TLE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 2 (TLE2) ELISA Kit Customized Service Offer
  1. "Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development."Eur. J. Biochem. 258:339-349(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
  7. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The Groucho/TLE/Grg family of transcriptional co-repressors."Genome Biol. 9:R205.1-R205.7(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]