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Transducin Like Enhancer Of Split 1 (TLE1)

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ESG; ESG1; GRG1; Enhancer Of Split Groucho 1

Transducin Like Enhancer Of Split 1 (TLE1)
CCC M371
HGNC 11837
MGI 104636
PubMed 17255769
RGD 1309237
UniProt Q04724
Wiki TLE1
TLE1 binds to the Runt domain and the C terminus of AML1 (RUNX1), but not to CBFB, mainly through the SP domain but also through the WD-40 domain of TLE1. Binding of TLE1 to the C terminus of RUNX1 inhibits RUNX1-induced transactivation of the CSF1 receptor (CSF1R). Northern blot analysis detected TLE1 transcripts of 4.4 and 2.6 kb. Expression was highest in skeletal muscle and liver, moderate in placenta, heart, kidney, and spleen, and weak in all other tissues examined, including brain.Mutation analysis showed that both the AF1 and AF2 domains of Esrrg2 were required for TLE1-dependent transactivation. The WD40 domain of TLE1 was required for interaction with Esrrg2, and the GP and Q domains of TLE1 were important for Esrrg2 coactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) ELISA Kit Customized Service Offer
  1. "Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta."J. Biol. Chem. 275:18418-18423(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif."Biochem. Biophys. Res. Commun. 223:701-705(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain."Mol. Cell. Biol. 16:2670-2677(1996) [PubMed] [Europe PMC] [Abstract]
  8. "The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3."J. Biol. Chem. 272:26604-26610(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development."Eur. J. Biochem. 258:339-349(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors."Proc. Natl. Acad. Sci. U.S.A. 95:11590-11595(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats."J. Biol. Chem. 275:4383-4390(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis."Genes Dev. 15:3193-3207(2001) [PubMed] [Europe PMC] [Abstract]
  14. "A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression."J. Biol. Chem. 277:51049-51057(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma."Biochem. Biophys. Res. Commun. 312:975-982(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Six3 and Six6 activity is modulated by members of the groucho family."Development 130:185-195(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The Groucho/TLE/Grg family of transcriptional co-repressors."Genome Biol. 9:R205.1-R205.7(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4."BMB Rep. 44:199-204(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor."Structure 10:751-761(2002) [PubMed] [Europe PMC] [Abstract]