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Transducin Like Enhancer Of Split 3 (TLE3)

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ESG; ESG3; GRG3; Enhancer of split groucho-like protein 3

Transducin Like Enhancer Of Split 3 (TLE3)
CCC M369
HGNC 11839
MGI 104634
PubMed 19309506
RGD 620292
UniProt Q04726
Wiki TLE3
Stifani et al. (1992) described human homologs of Drosophila groucho protein; these were designated TLE for 'transducin-like enhancer of split.' By Southern analysis of genomic DNA from human/Chinese hamster somatic hybrid cell lines, Miyasaka et al. (1993) mapped the TLE3 gene to chromosome 15. Mouse Esg (for 'enhancer of split groucho'), the homolog of human TLE3, was found to be represented by transcripts of 3.3 kb and 4.0 kb only in testis. Richard et al. (1994) presented an integrated physical, expression, and genetic map of human chromosome 15. By PCR analysis, they concluded that the TLE3 gene lies in their region II: 15q14-q15.1. On the other hand, by fluorescence in situ hybridization, which may be more precise, Liu et al. (1996) mapped TLE3 to 15q22.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 3 (TLE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 3 (TLE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 3 (TLE3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 3 (TLE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 3 (TLE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 3 (TLE3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Like Enhancer Of Split 3 (TLE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Like Enhancer Of Split 3 (TLE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Like Enhancer Of Split 3 (TLE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Like Enhancer Of Split 3 (TLE3) ELISA Kit Customized Service Offer
  1. "Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta."J. Biol. Chem. 275:18418-18423(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The Groucho/TLE/Grg family of transcriptional co-repressors."Genome Biol. 9:R205.1-R205.7(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]