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Nasal embryonic LHRH Factor (NELF)

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NSMF; Nasal Embryonic Luteinizing Hormone Releasing Hormone Factor; NMDA receptor synaptonuclear signaling and neuronal migration factor

Nasal embryonic LHRH Factor (NELF)
CCC M358
HGNC 29843
MGI 1861755
PubMed 12612062
RGD 619819
UniProt Q6X4W1
NELF is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.
Nelf was expressed in peripheral and central nervous system tissues during embryonic development, including olfactory sensory cells and LHRH cells.One of the variants, NELF-v1, has 93 to 94% identity at the amino acid level to mouse and rat Nelf, and 4 other transcripts are also highly conserved among human, rat, and mouse. A 3.0-kb transcript is expressed most highly in the adult and fetal brain, testis, and kidney, indicating that NELF plays a role in the function of these tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nasal embryonic LHRH Factor (NELF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nasal embryonic LHRH Factor (NELF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nasal embryonic LHRH Factor (NELF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nasal embryonic LHRH Factor (NELF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nasal embryonic LHRH Factor (NELF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nasal embryonic LHRH Factor (NELF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nasal embryonic LHRH Factor (NELF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nasal embryonic LHRH Factor (NELF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nasal embryonic LHRH Factor (NELF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nasal embryonic LHRH Factor (NELF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nasal embryonic LHRH Factor (NELF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nasal embryonic LHRH Factor (NELF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nasal embryonic LHRH Factor (NELF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nasal embryonic LHRH Factor (NELF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nasal embryonic LHRH Factor (NELF) ELISA Kit Customized Service Offer
  1. "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)."J. Hum. Genet. 49:265-268(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration."Mol. Cell. Endocrinol. 319:47-55(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism."Proc. Natl. Acad. Sci. U.S.A. 108:11524-11529(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]