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Transcription Factor Dp2 (TFDP2)

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E2F Dimerization Partner 2

Transcription Factor Dp2 (TFDP2)
CCC M356
HGNC 11751
MGI 107167
PubMed 9027491
RGD 1305814
UniProt Q14188
Wiki TFDP2
Zhang and Chellappan (1995) cloned an E2F dimerization partner, transcription factor DP2, from a human kidney cDNA library. The TFDP2 gene encodes a predicted 386-amino acid protein that is 68% identical to TFDP1. Northern blot analysis revealed 5 distinct transcript sizes ranging from 1.4 to 9.5 kb, with expression of at least one size observed in all cell lines tested. TFDP2 is able to form a functional heterodimer with E2F1.Zhang et al. (1997) used fluorescence in situ hybridization to map the TFDP2 gene to human chromosome 3q23.
High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor Dp2 (TFDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor Dp2 (TFDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor Dp2 (TFDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor Dp2 (TFDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor Dp2 (TFDP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor Dp2 (TFDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor Dp2 (TFDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor Dp2 (TFDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor Dp2 (TFDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor Dp2 (TFDP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor Dp2 (TFDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor Dp2 (TFDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor Dp2 (TFDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor Dp2 (TFDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor Dp2 (TFDP2) ELISA Kit Customized Service Offer
  1. "In vivo association of E2F and DP family proteins."Mol. Cell. Biol. 15:2536-2546(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of human DP2, a novel dimerization partner of E2F."Oncogene 10:2085-2093(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo."Proc. Natl. Acad. Sci. U.S.A. 93:7594-7599(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."Cell 123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes."Mol. Cell. Biol. 30:2293-2304(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP."Genes Dev. 13:666-674(1999) [PubMed] [Europe PMC] [Abstract]