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T Complex Protein 1 (TCP1)

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CCT-alpha; CCT1; CCTa; TCP-1-alpha; Chaperonin Containing TCP1, Subunit 1

T Complex Protein 1 (TCP1)
CCC M348
HGNC 11655
MGI 98535
PubMed 3476253
RGD 3832
UniProt P17987
Wiki TCP1
TCP1 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.The finding was confirmed by means of a cDNA probe for the human TCP1 gene. TCP1 codes for a protein which is abundantly expressed in testes as well as in other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM348Hu01 Recombinant T Complex Protein 1 (TCP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to T Complex Protein 1 (TCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T Complex Protein 1 (TCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T Complex Protein 1 (TCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T Complex Protein 1 (TCP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T Complex Protein 1 (TCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T Complex Protein 1 (TCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T Complex Protein 1 (TCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T Complex Protein 1 (TCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T Complex Protein 1 (TCP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T Complex Protein 1 (TCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T Complex Protein 1 (TCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T Complex Protein 1 (TCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T Complex Protein 1 (TCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T Complex Protein 1 (TCP1) ELISA Kit Customized Service Offer
  1. "Nucleotide and amino-acid sequence of human testis-derived TCP1."Nucleic Acids Res. 18:4247-4247(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAR-2007) to UniProtKB
  6. "The human homologue of the mouse T-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region."EMBO J. 6:1967-1974(1987) [PubMed] [Europe PMC] [Abstract]
  7. "T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol."Nature 358:249-252(1992) [PubMed] [Europe PMC] [Abstract]
  8. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly."Proc. Natl. Acad. Sci. U.S.A. 107:1488-1493(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]