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TBC1 Domain Family, Member 3 (TBC1D3)

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TRE17; TBC1D3A; PRC17; Prostate cancer gene 17 protein; Rab GTPase-activating protein PRC17

TBC1 Domain Family, Member 3 (TBC1D3)
CCC M345
HGNC 19031
PubMed 18199687
UniProt Q8IZP1
Wiki TBC1D3
TBC1D3 is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.
The deduced protein contains a TBC domain found in proteins involved in RAB GTPase signaling. RT-PCR analysis of 15 human tissues detected expression of TBC1D3 in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine, and peripheral blood leukocytes.The TBC1D3 paralogs appeared to be differentially expressed in human tissues. TBC1D3 was the only paralog expressed in heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 3 (TBC1D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 3 (TBC1D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 3 (TBC1D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 3 (TBC1D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 3 (TBC1D3) ELISA Kit Customized Service Offer
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  9. "Diversity of human copy number variation and multicopy genes."Science 330:641-646(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation."Biochem. Biophys. Res. Commun. 434:388-393(2013) [PubMed] [Europe PMC] [Abstract]