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TBC1 Domain Family, Member 1 (TBC1D1)

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TBC; TBC1

TBC1 Domain Family, Member 1 (TBC1D1)
CCC M343
HGNC 11578
MGI 1889508
PubMed 21505148
RGD 1304562
UniProt Q86TI0
Wiki TBC1D1
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. The deduced 763-amino acid protein contains a TBC1 domain. RT-PCR ELISA detected highest TBC1D1 expression in kidney, testis, ovary, and corpus callosum. Expression was intermediate in all other adult and fetal tissues and specific adult brain regions examined.of Tbc1d1 in mouse skeletal muscle cells increased fatty acid uptake and oxidation, whereas overexpression of Tbc1d1 had the opposite effect. Recombinant congenic mice lacking Tbc1d1 showed reduced body weight, decreased respiratory quotient, increased fatty acid oxidation, and reduced glucose uptake in isolated skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 1 (TBC1D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 1 (TBC1D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 1 (TBC1D1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 1 (TBC1D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 1 (TBC1D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 1 (TBC1D1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBC1 Domain Family, Member 1 (TBC1D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBC1 Domain Family, Member 1 (TBC1D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBC1 Domain Family, Member 1 (TBC1D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBC1 Domain Family, Member 1 (TBC1D1) ELISA Kit Customized Service Offer
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  9. "Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation."J. Biol. Chem. 286:18130-18138(2011) [PubMed] [Europe PMC] [Abstract]
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  11. "R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population."Hum. Mol. Genet. 17:1798-1802(2008) [PubMed] [Europe PMC] [Abstract]