≡

Transcriptional Adaptor 2 Beta (TADA2b)

[Edit]

ADA2-like protein beta

Transcriptional Adaptor 2 Beta (TADA2b)
CCC M333
HGNC 30781
MGI 3035274
PubMed 12972612
UniProt Q86TJ2
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery .
The predicted 420-amino acid human protein shares 100% identity with mouse Ada2b and 59% similarity with human ADA2A (TADA2A). Database analysis identified ADA2B homologs in Drosophila and Arabidopsis. Western blot analysis detected a 55- to 62-kD ADA2B protein in the nuclear fraction of HeLa cells.ADA2B did not coimmunoprecipitate with the PCAF complex, but it did interact with PCAF, GCN5, and the chromatin remodeling Swi/Snf complex protein BAF57 in yeast 2-hybrid analyses. Several assays showed that ADA2B associated with BAF57-/BRG1-containing complexes in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcriptional Adaptor 2 Beta (TADA2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcriptional Adaptor 2 Beta (TADA2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcriptional Adaptor 2 Beta (TADA2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcriptional Adaptor 2 Beta (TADA2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Adaptor 2 Beta (TADA2b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcriptional Adaptor 2 Beta (TADA2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcriptional Adaptor 2 Beta (TADA2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcriptional Adaptor 2 Beta (TADA2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcriptional Adaptor 2 Beta (TADA2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Adaptor 2 Beta (TADA2b) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription."Mol. Cell. Biol. 23:6944-6957(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation."Oncogene 26:5341-5357(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]