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Switch Associated Protein 70 (SWAP70)

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SWAP Switching B-cell Complex 70kDa Subunit

Switch Associated Protein 70 (SWAP70)
CCC M330
HGNC 17070
MGI 1298390
PubMed 21360565
RGD 1305579
UniProt Q9UH65
Wiki SWAP70
SWAP70 specifically binds phosphatidylinositol-3,4,5-triphosphate. On stimulation by growth factors, cytoplasmic SWAP70, which is dependent on phosphoinositide-3-hydroxykinase but independent of Ras, moved to cell membrane rearrangements known as ruffles. However, mutant SWAP70 lacking the ability to bind phosphatidylinositol-3,4,5-triphosphate blocked membrane ruffling induced by epidermal growth factor (EGF) or platelet-derived growth factor. SWAP70 shows low homology with Rac-guanine nucleotide exchange factors, and catalyzes phosphatidylinositol-3,4,5-triphosphate-dependent guanine nucleotide exchange to Rac. SWAP70-deficient fibroblasts showed impaired membrane ruffling after stimulation with EGF, and failed to activate Rac fully.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Switch Associated Protein 70 (SWAP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Switch Associated Protein 70 (SWAP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Switch Associated Protein 70 (SWAP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Switch Associated Protein 70 (SWAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Switch Associated Protein 70 (SWAP70) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Switch Associated Protein 70 (SWAP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Switch Associated Protein 70 (SWAP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Switch Associated Protein 70 (SWAP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Switch Associated Protein 70 (SWAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Switch Associated Protein 70 (SWAP70) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Switch Associated Protein 70 (SWAP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Switch Associated Protein 70 (SWAP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Switch Associated Protein 70 (SWAP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Switch Associated Protein 70 (SWAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Switch Associated Protein 70 (SWAP70) ELISA Kit Customized Service Offer
  1. "Association of SWAP-70 with the B cell antigen receptor complex."Proc. Natl. Acad. Sci. U.S.A. 97:2180-2184(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency."Clin. Immunol. 101:270-275(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SWAP-70 identifies a transitional subset of actin filaments in motile cells."Mol. Biol. Cell 14:3242-3253(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Solution structure of the PH domain of KIAA0640 protein from human."Submitted (OCT-2006) to the PDB data bank