≡

Survival Motor Neuron Domain Containing Protein 1 (SMNDC1)

[Edit]

SMNR; SPF30; Survival Of Motor Neuron Related Splicing Factor 30; 30 kDa splicing factor SMNrp; SMN-related protein

Survival Motor Neuron Domain Containing Protein 1 (SMNDC1)
CCC M328
HGNC 16900
MGI 1923729
PubMed 23850713
RGD 1309151
UniProt O75940
Wiki SMNDC1
SMN orthologs have been identified in the nematode C. elegans and in the fission yeast S. pombe, suggesting a highly conserved or 'housekeeping' function for the gene.
The SMNR gene encodes a novel protein of 239 amino acids which had recently been identified as a constituent of the spliceosome complex and designated SPF30 by Neubauer et al. (1998). Northern blot analysis showed that SMNR is differentially expressed with abundant levels in skeletal muscle. Talbot et al. (1998) mapped the SMNR gene to 10q23 by PCR analysis of a panel of somatic cell hybrids, followed by identification of an STS that had been mapped to the Whitehead Institute Radiation Hybrid Panel corresponding to the 10q linkage group.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Polyclonal Antibody Customized Service Offer
Assay Kits SEM328Hu ELISA Kit for Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Survival Motor Neuron Domain Containing Protein 1 (SMNDC1) ELISA Kit Customized Service Offer
  1. "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex."Nat. Genet. 20:46-50(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex."Hum. Mol. Genet. 7:2149-2156(1998) [PubMed] [Europe PMC] [Abstract]
  6. "SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome."EMBO J. 20:2304-2314(2001) [PubMed] [Europe PMC] [Abstract]
  7. "SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome."J. Biol. Chem. 276:31142-31150(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins."Nat. Struct. Mol. Biol. 18:1414-1420(2011) [PubMed] [Europe PMC] [Abstract]