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Suppressor Of Fused Homolog (SUFU)

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SUFUH; SUFUXL

Suppressor Of Fused Homolog (SUFU)
CCC M322
HGNC 16466
MGI 1345643
PubMed 15656799
RGD 1559462
UniProt Q9UMX1
SUFU encodes a component of the sonic hedgehog (SHH) / patched (PTCH) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes
The deduced 484-amino acid protein is 40% identical to the fly protein. Northern blot analysis detected ubiquitous expression of a minor 2.8-kb and a major 5.5-kb transcript. Whole-mount in situ hybridization analysis detected expression throughout mid gestation in the neural tube and, later, in the neural tube's brain and spinal cord derivatives, overlapping with expression of Ptch and Gli1 , Gli2 , and Gli3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Fused Homolog (SUFU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Fused Homolog (SUFU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Fused Homolog (SUFU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Fused Homolog (SUFU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Fused Homolog (SUFU) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Fused Homolog (SUFU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Fused Homolog (SUFU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Fused Homolog (SUFU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Fused Homolog (SUFU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Fused Homolog (SUFU) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Fused Homolog (SUFU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Fused Homolog (SUFU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Fused Homolog (SUFU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Fused Homolog (SUFU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Fused Homolog (SUFU) ELISA Kit Customized Service Offer
  1. "Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli."J. Cell Sci. 112:4437-4448(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1."Nat. Cell Biol. 1:312-319(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in SUFU predispose to medulloblastoma."Nat. Genet. 31:306-310(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Suppressor of fused gene involved in hedgehog signal transduction in Drosophila melanogaster is conserved in mammals."Dev. Genes Evol. 209:294-300(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Gli regulation by the opposing activities of fused and suppressor of fused."Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway."J. Biol. Chem. 285:30079-30090(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner."Cell. Signal. 24:1222-1228(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Suppressor of fused regulates Gli activity through a dual binding mechanism."Mol. Cell. Biol. 24:8627-8641(2004) [PubMed] [Europe PMC] [Abstract]