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SCL/TAL1 Interrupting Locus Protein (STIL)

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SIL; MCPH7

SCL/TAL1 Interrupting Locus Protein (STIL)
CCC M316
HGNC 10879
MGI 107477
PubMed 19215732
RGD 1304972
UniProt Q15468
Wiki STIL
STIL encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCL/TAL1 Interrupting Locus Protein (STIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCL/TAL1 Interrupting Locus Protein (STIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCL/TAL1 Interrupting Locus Protein (STIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCL/TAL1 Interrupting Locus Protein (STIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCL/TAL1 Interrupting Locus Protein (STIL) ELISA Kit Customized Service Offer
  1. "Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia."Mol. Cell. Biol. 11:5462-5469(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly."Cytogenet. Genome Res. 97:62-67(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia."EMBO J. 9:3343-3351(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity."Science 250:1426-1429(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia."Blood 79:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of the SIL gene is correlated with growth induction and cellular proliferation."Cell Growth Differ. 8:1171-1179(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints."J. Biol. Chem. 276:29126-29133(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR."Leuk. Res. 27:575-582(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951." Blood 103:442-450(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Sil overexpression in lung cancer characterizes tumors with increased mitotic activity."Oncogene 23:5371-5377(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint."Mol. Cell. Biol. 25:6660-6672(2005) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly."Am. J. Hum. Genet. 84:286-290(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Investigation of primary microcephaly in Bushehr province of Iran: novel STIL and ASPM mutations."Clin. Genet. 83:488-490(2013) [PubMed] [Europe PMC] [Abstract]