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Sialyltransferase 8 (SIAT8)

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ST8SIA1; GD3S; SIAT8A; ST8Sia I; ST8SiaI; ST8 Alpha N-Acetyl Neuraminide Alpha 2,8-Sialyltransferase 1; Ganglioside GT3 synthase; Ganglioside GD3 synthase

Sialyltransferase 8 (SIAT8)
CCC M301
HGNC 10869
MGI 106011
PubMed 7901202
RGD 3679
UniProt Q92185
Wiki ST8SIA1
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3.
ST8SIA1 may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.The cDNA encodes a 341-amino acid protein containing a single transmembrane domain in its N-terminal region. The amino acid sequence of GD3 synthase shows a high level of similarity with those of other sialyltransferases at 2 conserved regions, both of which are the so-called sialyl motif typical of the sialyltransferase family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 8 (SIAT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 8 (SIAT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 8 (SIAT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 8 (SIAT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 8 (SIAT8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 8 (SIAT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 8 (SIAT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 8 (SIAT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 8 (SIAT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 8 (SIAT8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 8 (SIAT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 8 (SIAT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 8 (SIAT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 8 (SIAT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 8 (SIAT8) ELISA Kit Customized Service Offer
  1. "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase)."J. Biol. Chem. 269:15950-15956(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells."Proc. Natl. Acad. Sci. U.S.A. 91:7952-7956(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody."Proc. Natl. Acad. Sci. U.S.A. 91:10455-10459(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme."J. Biol. Chem. 271:3684-3691(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]