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Sialyltransferase 4C (SIAT4C)

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NANTA3; SAT3; SIAT4; ST3GAL4; ST3GalIV; STZ; ST3 Beta Galactoside Alpha-2,3-Sialyltransferase 4; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Sialyltransferase 4C (SIAT4C)
CCC M294
HGNC 10864
MGI 1316743
PubMed 8557707
RGD 1303068
UniProt Q11206
Wiki ST3GAL4
Synthesis of alpha-2,3-linked sialic acid to Gal(beta-1,3)GalNAc is mediated by at least 3 distinct beta-galactoside alpha-2,3-sialyltransferases, including ST3GAL4. Previous characterization of ST3GAL4 cDNAs revealed that the gene produces at least 3 transcripts in human placenta that code for identical proteins except at the 5-prime ends. Further screening for clones that contained the 5-prime end of the cDNA identified 2 additional distinct mRNAs that are expressed in human placenta. Comparison of the genomic DNA sequence with that of the 5 different mRNAs indicated that these transcripts are produced by a combination of alternative splicing and alternative promoter utilization. 1 of them is specifically expressed in placenta, testis, and ovary, indicating that its expression is independently regulated from the others.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 4C (SIAT4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 4C (SIAT4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 4C (SIAT4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 4C (SIAT4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 4C (SIAT4C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 4C (SIAT4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 4C (SIAT4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 4C (SIAT4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 4C (SIAT4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 4C (SIAT4C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 4C (SIAT4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 4C (SIAT4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 4C (SIAT4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 4C (SIAT4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 4C (SIAT4C) ELISA Kit Customized Service Offer
  1. "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase."J. Biol. Chem. 271:931-938(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups."J. Biol. Chem. 269:1394-1401(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection."J. Biol. Chem. 268:22782-22787(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues."Glycoconj. J. 18:759-767(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line."Biochemistry 35:5166-5174(1996) [PubMed] [Europe PMC] [Abstract]