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Spen Homolog, Transcriptional Regulator (SPEN)

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MINT; SHARP; RBM15C; Msx2-Interacting Protein; SMART/HDAC1-associated repressor protein

Spen Homolog, Transcriptional Regulator (SPEN)
CCC M270
HGNC 17575
MGI 1891706
PubMed 20079695
RGD 1590820
UniProt Q96T58
SPEN encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators.
The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spen Homolog, Transcriptional Regulator (SPEN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spen Homolog, Transcriptional Regulator (SPEN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spen Homolog, Transcriptional Regulator (SPEN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spen Homolog, Transcriptional Regulator (SPEN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spen Homolog, Transcriptional Regulator (SPEN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spen Homolog, Transcriptional Regulator (SPEN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spen Homolog, Transcriptional Regulator (SPEN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spen Homolog, Transcriptional Regulator (SPEN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spen Homolog, Transcriptional Regulator (SPEN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spen Homolog, Transcriptional Regulator (SPEN) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling."Proc. Natl. Acad. Sci. U.S.A. 99:2613-2618(2002) [PubMed] [Europe PMC] [Abstract]
  6. "SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway."EMBO J. 21:5417-5426(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export."J. Biol. Chem. 280:36935-36945(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling."Genes Dev. 17:1909-1920(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]