≡

Specificity Protein 3 (SP3)

[Edit]

SPR-2; Sp3 Transcription Factor

Specificity Protein 3 (SP3)
CCC M266
HGNC 11208
MGI 1277166
PubMed 21085687
RGD 1583765
UniProt Q02447
Wiki SP3
SP3 belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes.
This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Specificity Protein 3 (SP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Specificity Protein 3 (SP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Specificity Protein 3 (SP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Specificity Protein 3 (SP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Specificity Protein 3 (SP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Specificity Protein 3 (SP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Specificity Protein 3 (SP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Specificity Protein 3 (SP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Specificity Protein 3 (SP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Specificity Protein 3 (SP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Specificity Protein 3 (SP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Specificity Protein 3 (SP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Specificity Protein 3 (SP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Specificity Protein 3 (SP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Specificity Protein 3 (SP3) ELISA Kit Customized Service Offer
  1. "AUA as a translation initiation site in vitro for the human transcription factor Sp3."J. Biochem. Mol. Biol. 35:273-282(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis."Gene 341:235-247(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "5' genomic structure of human Sp3."Mol. Biol. Evol. 19:2026-2029(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression."Mol. Cell. Biol. 12:4251-4261(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes."Nucleic Acids Res. 20:5519-5525(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Sp3 is a transcriptional activator of the human alpha2(I) collagen gene."Nucleic Acids Res. 25:3712-3717(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene."J. Biol. Chem. 274:19573-19580(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Transcription factor Sp3 is regulated by acetylation."Nucleic Acids Res. 29:4994-5000(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2."J. Biol. Chem. 277:35783-35786(2002) [PubMed] [Europe PMC] [Abstract]
  12. "SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization."Mol. Cell 10:831-842(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Acetylated SP3 is a transcriptional activator."J. Biol. Chem. 278:35775-35780(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Complexity of translationally controlled transcription factor Sp3 isoform expression."J. Biol. Chem. 279:42095-42105(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism."Cell. Signal. 17:153-166(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Sp3 is involved in the regulation of SOCS3 gene expression."Biochem. J. 387:737-745(2005) [PubMed] [Europe PMC] [Abstract]
  17. "The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter."Gene 379:68-78(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1."FASEB J. 21:3386-3397(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Nuclear organization and chromatin dynamics -- Sp1, Sp3 and histone deacetylases."Adv. Enzyme Regul. 48:189-208(2008) [PubMed] [Europe PMC] [Abstract]
  20. "SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing."EMBO Rep. 9:899-906(2008) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]