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Sorbin And SH3 Domain Containing Protein 3 (SORBS3)

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SCAM-1; SH3D4; Vinexin; SH3-containing adapter molecule 1

Sorbin And SH3 Domain Containing Protein 3 (SORBS3)
CCC M263
HGNC 30907
MGI 700013
PubMed 24004948
RGD 628900
UniProt O60504
Wiki SORBS3
The SORBS3 gene encodes 2 isoforms vinexin-alpha and -beta that are vinculin (VCL)-binding cytoskeletal proteins involved in focal adhesion and cell-cell adhesion.The 733-amino acid mouse vinexin-alpha and the 328-amino acid mouse vinexin-beta have deduced molecular masses of 87 kD and 37 kD, respectively. Sequence analysis of the 5-prime UTRs of the human and mouse cDNAs, suggested that 2 distinct alternative promoters give rise to the 2 mRNA species. Vinexin-beta corresponds to the C-terminal half of vinexin-alpha, and both species share a region containing 3 SH3 domains. Northern blot analysis detected a 2.0-kb transcript in all human tissues examined with highest expression in heart, placenta, and pancreas, moderate expression in brain and liver, and low expression in lung, skeletal muscle, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorbin And SH3 Domain Containing Protein 3 (SORBS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorbin And SH3 Domain Containing Protein 3 (SORBS3) ELISA Kit Customized Service Offer
  1. "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization."J. Cell Biol. 144:59-69(1999) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities."J. Biol. Chem. 274:35933-35937(1999) [PubMed] [Europe PMC] [Abstract]
  5. "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor."J. Biol. Chem. 278:20059-20068(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
  7. "SHIP2 interaction with the cytoskeletal protein Vinexin."FEBS J. 272:6052-6066(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of SH3 domains of human vinexin."Submitted (OCT-2006) to the PDB data bank
  20. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]