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Smad Nuclear Interacting Protein 1 (SNIP1)

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FHA domain-containing protein SNIP1

Smad Nuclear Interacting Protein 1 (SNIP1)
CCC M258
HGNC 30587
MGI 2156003
PubMed 22279524
RGD 1359268
UniProt Q8TAD8
Wiki SNIP1
The deduced 396-amino acid protein has a calculated molecular mass of about 50 kD. SNIP1 contains an N-terminal bipartite nuclear localization signal and a C-terminal forkhead-associated domain. Northern blot analysis detected transcripts of 4.4, 2.4, and 1.5 kb in all tissues examined, with highest expression in heart and skeletal muscle. Western blot analysis of several cell lines showed that SNIP1 has an apparent molecular mass of about 50 kD. Western blot analysis of multiple adult mouse tissues detected Snip1 in all tissues examined. Immunohistochemical analysis of rat kidney sections detected Snip1 localized specifically to epithelial elements. Indirect immunofluorescence demonstrated that mouse Snip1 localized to the nucleus in a mouse mammary cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Nuclear Interacting Protein 1 (SNIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Nuclear Interacting Protein 1 (SNIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Nuclear Interacting Protein 1 (SNIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Nuclear Interacting Protein 1 (SNIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smad Nuclear Interacting Protein 1 (SNIP1) ELISA Kit Customized Service Offer
  1. "A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction."Genes Dev. 14:1605-1616(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators."J. Biol. Chem. 276:46297-46304(2001) [PubMed] [Europe PMC] [Abstract]
  5. "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)."BMC Cell Biol. 3:15-15(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression."Oncogene 23:8185-8195(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "PDSM, a motif for phosphorylation-dependent SUMO modification."Proc. Natl. Acad. Sci. U.S.A. 103:45-50(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of cyclin D1 RNA stability by SNIP1."Cancer Res. 68:7621-7628(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis."Proc. Natl. Acad. Sci. U.S.A. 105:10073-10078(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Genetic mapping and exome sequencing identify variants associated with five novel diseases." PLoS ONE 7:E28936-E28936(2012) [PubMed] [Europe PMC] [Abstract]