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Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2)

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PTFdelta; SNAP45; snRNA-activating protein complex 45 kDa subunit; Proximal sequence element-binding transcription factor subunit delta

Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2)
CCC M254
HGNC 11135
MGI 1914861
PubMed 8633057
RGD 1304589
UniProt Q13487
Wiki SNAPC2
Eukaryotic RNA polymerases I (pol I), II (pol II), and III (pol III) initiate RNA synthesis only in the presence of distinct sets of additional proteins, called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase.
Sequence analysis predicted that the deduced 334-amino acid SNAPC2 is an acidic (pI of 5.7), proline-rich (13.8% of all residues) protein. Immunodepletion experiments showed that SNAPC2 is required for the transcription of both pol II- and pol III-dependent snRNA genes. Immunoblot analysis suggested that in the presence of high salt, the SNAPC subunits bind more strongly with each other than they do with TBP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear RNA Activating Complex Polypeptide 2 (SNAPC2) ELISA Kit Customized Service Offer
  1. "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein."Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1."Mol. Cell. Biol. 18:368-377(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]