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SET And MYND Domain Containing Protein 3 (SMYD3)

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ZMYND1; ZNFN3A1; KMT3E; Zinc Finger,MYND Domain Containing 1; Histone-lysine N-methyltransferase SMYD3

SET And MYND Domain Containing Protein 3 (SMYD3)
CCC M252
HGNC 15513
MGI 1916976
PubMed 22419068
RGD 1562635
UniProt Q9H7B4
Wiki SMYD3
SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.
The deduced 428-amino acid protein contains an N-terminal MYND-type zinc finger domain, followed by a SET domain. Northern blot analysis detected a 1.7-kb transcript that was specific to testis and skeletal muscle. Immunohistochemical staining indicated that the subcellular localization of SMYD3 was altered by the density of cultured human hepatoma cells. In synchronized cells, SMYD3 was located mainly in the cytoplasm when the cells were arrested at G0/G1, but it accumulated in the nuclei at S phase and G2/M.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET And MYND Domain Containing Protein 3 (SMYD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET And MYND Domain Containing Protein 3 (SMYD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET And MYND Domain Containing Protein 3 (SMYD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET And MYND Domain Containing Protein 3 (SMYD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET And MYND Domain Containing Protein 3 (SMYD3) ELISA Kit Customized Service Offer
  1. "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells."Nat. Cell Biol. 6:731-740(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation."Epigenetics 7:340-343(2012) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human histone-lysine n-methyltransferase SMYD3 in complex with S-adenosyl-L-methionine."Submitted (APR-2010) to the PDB data bank