≡

Structural Maintenance Of Chromosomes Protein 5 (SMC5)

[Edit]

SMC5L; SMC5L1

Structural Maintenance Of Chromosomes Protein 5 (SMC5)
CCC M250
HGNC 20465
MGI 2385088
PubMed 17589526
RGD 1307492
UniProt Q8IY18
Wiki SMC5
Mutant Smc5/Smc6 cells underwent an aberrant mitosis in which chromosome segregation of repetitive regions was impaired, leading to DNA damage and Rad9-dependent activation of the Rad53 (CHEK2) protein kinase. Following Smc5/Smc6 inactivation, metaphase-arrested cells showed increased levels of X-shaped DNA (Holliday junctions) at the rDNA locus.
The transcript contains an Alu repetitive element in the 3-prime untranslated region, and the deduced 882-amino acid protein shares weak homology with Saccharomyces pombe Rad18, a DNA repair protein. RT-PCR detected SMC5 expression in all tissues examined, with highest levels in heart, placenta, lung, liver, skeletal muscle, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 5 (SMC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 5 (SMC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 5 (SMC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 5 (SMC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 5 (SMC5) ELISA Kit Customized Service Offer
  1. "Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex."Mol. Biol. Cell 12:1583-1594(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human MMS21/NSE2 is a SUMO ligase required for DNA repair."Mol. Cell. Biol. 25:7021-7032(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks."EMBO J. 25:3377-3388(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins."Nat. Struct. Mol. Biol. 14:581-590(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex."Mol. Cell. Biol. 28:1197-1206(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "SMC5 and MMS21 are required for chromosome cohesion and mitotic progression."Cell Cycle 8:2211-2218(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]