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Structural Maintenance Of Chromosomes Protein 4 (SMC4)

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CAPC; SMC4L1; hCAP-C; XCAP-C homolog; Chromosome-associated polypeptide C

Structural Maintenance Of Chromosomes Protein 4 (SMC4)
CCC M249
HGNC 14013
MGI 1917349
PubMed 10485849
RGD 1306680
UniProt Q9NTJ3
Wiki SMC4
Sequence analysis predicted that the 1,202-amino acid CAPC protein lacks the first 80 residues of the frog sequence but is homologous in the middle coiled-coil region. Northern blot analysis detected a 5.0-kb transcript. Western blot and immunoprecipitation analyses showed that CAPC is expressed as a 165-kD soluble nuclear protein throughout the cell cycle in a variety of cell lines and is associated with CAPE in a heterodimeric complex. Immunofluorescence analysis demonstrated that the proteins are associated with condensed chromosomes in mitotic cells and show dense speckles in interphase nuclei. Microinjection of anti-CAPC or anti-CAPE failed to arrest mitosis in metaphase cells, in contrast to antibody to SMC1L1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 4 (SMC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 4 (SMC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 4 (SMC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 4 (SMC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 4 (SMC4) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family."J. Hum. Genet. 44:197-202(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics."Proc. Natl. Acad. Sci. U.S.A. 95:12906-12911(1998) [PubMed] [Europe PMC] [Abstract]
  6. "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation."Mol. Cell. Biol. 20:6996-7006(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Chromosome condensation by a human condensin complex in Xenopus egg extracts."J. Biol. Chem. 276:5417-5420(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]