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Structural Maintenance Of Chromosomes Protein 1A (SMC1A)

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DXS423E; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB

Structural Maintenance Of Chromosomes Protein 1A (SMC1A)
CCC M246
HGNC 11111
MGI 1344345
PubMed 23638217
RGD 61991
UniProt Q14683
Wiki SMC1A
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. SMC1A, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 1A (SMC1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 1A (SMC1A) ELISA Kit Customized Service Offer
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  7. "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins."J. Biol. Chem. 272:24081-24087(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins."Mol. Cell. Biol. 19:5417-5428(1999) [PubMed] [Europe PMC] [Abstract]
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  10. "Localization of human SMC1 protein at kinetochores."Chromosome Res. 10:267-277(2002) [PubMed] [Europe PMC] [Abstract]
  11. "MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation."Proc. Natl. Acad. Sci. U.S.A. 100:15387-15392(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates."Mol. Cell 18:185-200(2005) [PubMed] [Europe PMC] [Abstract]
  13. ErratumMol. Cell 18:609-609(2005)
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations."Nat. Genet. 38:528-530(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation."Am. J. Hum. Genet. 80:485-494(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Incidence and clinical features of X-linked Cornelia de Lange syndrome due to SMC1L1 mutations."Hum. Mutat. 28:205-206(2007) [PubMed] [Europe PMC] [Abstract]
  25. "Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA."Hum. Mol. Genet. 18:418-427(2009) [PubMed] [Europe PMC] [Abstract]
  26. "SMC1A expression and mechanism of pathogenicity in probands with X-Linked Cornelia de Lange syndrome."Hum. Mutat. 30:1535-1542(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome." Am. J. Med. Genet. A 152:924-929(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Hypertrophic cardiomyopathy in a girl with Cornelia de Lange syndrome due to mutation in SMC1A."Am. J. Med. Genet. A 152:2127-2129(2010) [PubMed] [Europe PMC] [Abstract]