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Secreted Ly6/uPAR Related Protein 1 (SLURP1)

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ARS; ANUP; ArsB; LY6LS; MDM; Lymphocyte Antigen 6-Like Secreted; ARS Component B; Anti-neoplastic urinary protein

Secreted Ly6/uPAR Related Protein 1 (SLURP1)
CCC M240
HGNC 18746
MGI 1930923
PubMed 23139280
RGD 1308768
UniProt P55000
Wiki SLURP1
SLURP1 is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
The Ly6/uPAR protein family can be divided into 2 subfamilies. One comprises glycosylphosphatidylinositol (GPI)-anchored glycoprotein receptors with 10 cysteine residues. The other subfamily includes the secreted single-domain snake and frog cytotoxins, and its members generally possess only 8 cysteines and no GPI-anchoring signal sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM240Hu01 Recombinant Secreted Ly6/uPAR Related Protein 1 (SLURP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM240Hu01 Polyclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1) WB; IHC; ICC; IP.
Assay Kits SEM240Hu ELISA Kit for Secreted Ly6/uPAR Related Protein 1 (SLURP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM240Mu01 Recombinant Secreted Ly6/uPAR Related Protein 1 (SLURP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPM240Mu02 Recombinant Secreted Ly6/uPAR Related Protein 1 (SLURP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM240Mu01 Polyclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1) WB; IHC; ICC; IP.
Assay Kits SEM240Mu ELISA Kit for Secreted Ly6/uPAR Related Protein 1 (SLURP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Secreted Ly6/uPAR Related Protein 1 (SLURP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Secreted Ly6/uPAR Related Protein 1 (SLURP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Secreted Ly6/uPAR Related Protein 1 (SLURP1) ELISA Kit Customized Service Offer
  1. "Biological effects of SLURP-1 on human keratinocytes."J. Invest. Dermatol. 125:1236-1241(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes."Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily."Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract]
  5. "ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]
  6. "SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda."J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the gene encoding SLURP-1 in Mal de Meleda."Hum. Mol. Genet. 10:875-880(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Heterozygous manifestations in female carriers of Mal de Meleda."Clin. Genet. 65:244-246(2004) [PubMed] [Europe PMC] [Abstract]