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Stem Loop Binding Protein (SLBP)

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HBP; Histone Binding Protein; Histone stem-loop-binding protein; Histone RNA hairpin-binding protein

Stem Loop Binding Protein (SLBP)
CCC M238
HGNC 10904
MGI 108402
PubMed 23804756
RGD 1584682
UniProt Q14493
Wiki SLBP
SLBP encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
Database searches revealed that the genomic region of HBP had previously been sequenced during the search for the Huntington disease locus on 4p16.3. The HBP gene has 8 exons covering approximately 19.5 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stem Loop Binding Protein (SLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stem Loop Binding Protein (SLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stem Loop Binding Protein (SLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stem Loop Binding Protein (SLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stem Loop Binding Protein (SLBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stem Loop Binding Protein (SLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stem Loop Binding Protein (SLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stem Loop Binding Protein (SLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stem Loop Binding Protein (SLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stem Loop Binding Protein (SLBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stem Loop Binding Protein (SLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stem Loop Binding Protein (SLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stem Loop Binding Protein (SLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stem Loop Binding Protein (SLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stem Loop Binding Protein (SLBP) ELISA Kit Customized Service Offer
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  2. "The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing."Genes Dev. 10:3028-3040(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein."EMBO J. 16:769-778(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing."Genes Dev. 16:58-71(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase."Mol. Cell. Biol. 23:1590-1601(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear import of the stem-loop binding protein and localization during the cell cycle."Mol. Biol. Cell 16:2960-2971(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1."Nat. Struct. Mol. Biol. 12:794-800(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA."J. Biol. Chem. 281:30447-30454(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
  14. "SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein."Mol. Cell. Biol. 28:1182-1194(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase."Mol. Cell. Biol. 28:4469-4479(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Knockdown of SLBP results in nuclear retention of histone mRNA."RNA 15:459-472(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization."Biochemistry 51:3215-3231(2012) [PubMed] [Europe PMC] [Abstract]