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Src Like Adapter 2 (SLA2)

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SLAP2; C20orf156; MARS; Modulator of antigen receptor signaling

Src Like Adapter 2 (SLA2)
CCC M237
HGNC 17329
MGI 1925049
PubMed 21849475
RGD 1562071
UniProt Q9H6Q3
Wiki SLA2
SLA2 encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.SLA2 plays an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. Mutation analysis established that the N-terminal myristoylation site of SLA2 is critical for function in both B and T lymphocytes and is necessary for SLA2 expression in the membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Src Like Adapter 2 (SLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Src Like Adapter 2 (SLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Src Like Adapter 2 (SLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Src Like Adapter 2 (SLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Src Like Adapter 2 (SLA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Src Like Adapter 2 (SLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Src Like Adapter 2 (SLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Src Like Adapter 2 (SLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Src Like Adapter 2 (SLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Src Like Adapter 2 (SLA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Src Like Adapter 2 (SLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Src Like Adapter 2 (SLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Src Like Adapter 2 (SLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Src Like Adapter 2 (SLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Src Like Adapter 2 (SLA2) ELISA Kit Customized Service Offer
  1. "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling." J. Exp. Med. 194:1263-1276(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v."Oncogene 22:266-273(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling."J. Biol. Chem. 277:19131-19138(2002) [PubMed] [Europe PMC] [Abstract]