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The mouse Sno gene expresses 2 isoforms, SnoN and SnoN2, that are different from each other in a location downstream of the site of alternative splicing previously described in the human SNO gene. SnoN2 is missing a 138-bp coding segment present in mouse SnoN and human SNON. TGFB induces activation and nuclear translocation of SMAD2, SMAD3, and SMAD4. SMAD3 causes degradation of SnoN, allowing a SMAD2/SMAD4 complex to activate TGFB target genes. To initiate a negative feedback mechanism that permits a precise and timely regulation of TGFB signaling, TGFB also induces an increased expression of SnoN at a later stage, which in turn binds to SMAD heteromeric complexes and shuts off TGFB signaling.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPM234Hu01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAM234Hu01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| MAM234Hu21 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. | |
| Assay Kits | SEM234Hu | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant SKI Like Oncogene (SKIL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to SKI Like Oncogene (SKIL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to SKI Like Oncogene (SKIL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for SKI Like Oncogene (SKIL) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant SKI Like Oncogene (SKIL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to SKI Like Oncogene (SKIL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to SKI Like Oncogene (SKIL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for SKI Like Oncogene (SKIL) | ELISA Kit Customized Service Offer |
- "Isolation of human cDNA clones of ski and the ski-related gene, sno."Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
- "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno."Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract]
- "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
- "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]