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CD27 Binding Protein (CD27BP)

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SIVA; SIVA1,Apoptosis-Inducing Factor; Apoptosis regulatory protein Siva

CD27 Binding Protein (CD27BP)
CCC M233
HGNC 17712
MGI 1353606
PubMed 19643733
RGD 1561872
UniProt O15304
Wiki 19643733
CD27BP encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.Sequence analysis predicted that the 189-amino acid protein has an N-terminal ring finger and a cys-rich C terminus containing death domains with homology to those in FADD and RIP, as well as motifs that may form a B box-like ring finger, although it lacks his residues and coiled-coil domain structures. Northern blot analysis revealed ubiquitous expression of a 0.8-kb transcript that was greatest in thymus and lowest in colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM233Hu01 Recombinant CD27 Binding Protein (CD27BP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM233Hu21 Monoclonal Antibody to CD27 Binding Protein (CD27BP) WB; IHC; ICC; IP.
PAM233Hu01 Polyclonal Antibody to CD27 Binding Protein (CD27BP) WB; IHC; ICC; IP.
Assay Kits SEM233Hu ELISA Kit for CD27 Binding Protein (CD27BP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD27 Binding Protein (CD27BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD27 Binding Protein (CD27BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD27 Binding Protein (CD27BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD27 Binding Protein (CD27BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD27 Binding Protein (CD27BP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD27 Binding Protein (CD27BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD27 Binding Protein (CD27BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD27 Binding Protein (CD27BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD27 Binding Protein (CD27BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD27 Binding Protein (CD27BP) ELISA Kit Customized Service Offer
  1. "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva."J. Virol. 74:4284-4290(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress."J. Biol. Chem. 276:11465-11468(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva."Virology 289:15-22(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis."Proc. Natl. Acad. Sci. U.S.A. 99:6925-6930(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis."Apoptosis 9:83-95(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway."J. Immunol. 172:4008-4017(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2."Cancer Res. 65:5301-5309(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22."Mol. Cell. Biochem. 287:147-155(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD)."Oncogene 25:3458-3462(2006) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]