≡

Seven In Absentia Homolog 1 (SIAH1)

[Edit]

HUMSIAH; Siah-1; Siah-1a; hSIAH1; E3 ubiquitin-protein ligase SIAH1

Seven In Absentia Homolog 1 (SIAH1)
CCC M228
HGNC 10857
MGI 108064
PubMed 22483617
RGD 620449
UniProt Q8IUQ4
Wiki SIAH1
SIAH1 is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.The deduced 195-amino acid SIAH1S protein is identical to SIAH1 for the first 192 amino acids. PCR analysis detected both SIAH1 and SIAH1S in human heart, lymph node, testis, and fetal brain. PCR and Western blot analysis detected SIAH1 and SIAH1S transcripts and proteins in breast, kidney, and esophagus cancer tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Seven In Absentia Homolog 1 (SIAH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Seven In Absentia Homolog 1 (SIAH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Seven In Absentia Homolog 1 (SIAH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Seven In Absentia Homolog 1 (SIAH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Seven In Absentia Homolog 1 (SIAH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Seven In Absentia Homolog 1 (SIAH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Seven In Absentia Homolog 1 (SIAH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Seven In Absentia Homolog 1 (SIAH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Seven In Absentia Homolog 1 (SIAH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Seven In Absentia Homolog 1 (SIAH1) ELISA Kit Customized Service Offer
  1. "Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression." Proc. Natl. Acad. Sci. U.S.A. 93:9039-9042(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human homologs of the Drosophila seven in absentia (sina) gene."Genomics 46:103-111(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene."Int. J. Cancer 87:794-797(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin."Oncogene 26:6319-6331(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway."Genes Dev. 11:2701-2714(1997) [PubMed] [Europe PMC] [Abstract]
  8. "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1."EMBO J. 17:2736-2747(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins."Mol. Cell. Biol. 19:724-732(1999) [PubMed] [Europe PMC] [Abstract]
  10. "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis."Oncogene 19:5997-6006(2000) [PubMed] [Europe PMC] [Abstract]
  11. "p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3."J. Biol. Chem. 275:15578-15585(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein."Mol. Cell 7:927-936(2001) [PubMed] [Europe PMC] [Abstract]
  14. "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1."EMBO J. 20:4143-4152(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of BOB.1/OBF.1 stability by SIAH."EMBO J. 20:4153-4162(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Siah-1 binds and regulates the function of Numb."Proc. Natl. Acad. Sci. U.S.A. 98:15067-15072(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue."J. Biol. Chem. 277:30754-30759(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Siah-1 facilitates ubiquitination and degradation of synphilin-1."J. Biol. Chem. 278:51504-51514(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1."Cancer Res. 63:3043-3048(2003) [PubMed] [Europe PMC] [Abstract]
  20. "SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas."Genes Chromosomes Cancer 36:283-291(2003) [PubMed] [Europe PMC] [Abstract]
  21. "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway."Oncogene 22:8845-8851(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)."J. Biol. Chem. 278:1837-1840(2003) [PubMed] [Europe PMC] [Abstract]
  23. "SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome."Hum. Mol. Genet. 13:1525-1534(2004) [PubMed] [Europe PMC] [Abstract]
  24. "The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome."J. Biol. Chem. 279:5374-5379(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease."Proc. Natl. Acad. Sci. U.S.A. 101:5500-5505(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR."Nat. Cell Biol. 10:812-824(2008) [PubMed] [Europe PMC] [Abstract]
  27. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation."J. Biol. Chem. 284:11706-11716(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation."Leukemia 24:1412-1421(2010) [PubMed] [Europe PMC] [Abstract]
  30. "The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription."Mol. Cell 46:325-334(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex."J. Biol. Chem. 280:34278-34287(2005) [PubMed] [Europe PMC] [Abstract]