≡

SNF2 Histone Linker PHD RING Helicase (SHPRH)

[Edit]

E3 ubiquitin-protein ligase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase

SNF2 Histone Linker PHD RING Helicase (SHPRH)
CCC M227
HGNC 19336
MGI 1917581
PubMed 18719106
RGD 1310342
UniProt Q8NBR7
Wiki SHPRH
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.The deduced 1,683-amino acid protein has a calculated molecular mass of about 193 kD. SHPRH contains 2 partial SNF2 domains and 1 each of PHD finger, RING finger, linker histone, and DEAD helicase domains. SHPRH also has a nuclear localization signal. The mouse and human proteins share about 86% amino acid identity, and homologous sequences were found in several lower animal species and plant. Northern blot analysis detected a transcript of about 7.5 kb in all human and mouse tissues examined. Expression levels were tissue specific. A minor band of about 9.5 kb was also detected in mouse brain, spleen, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Histone Linker PHD RING Helicase (SHPRH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Histone Linker PHD RING Helicase (SHPRH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Histone Linker PHD RING Helicase (SHPRH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Histone Linker PHD RING Helicase (SHPRH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Histone Linker PHD RING Helicase (SHPRH) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region."Genomics 82:153-161(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination."J. Cell Biol. 175:703-708(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen."Proc. Natl. Acad. Sci. U.S.A. 103:18107-18112(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks."Proc. Natl. Acad. Sci. U.S.A. 105:12411-12416(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]