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Shugoshin Like Protein 1 (SGOL1)

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NY-BR-85; Sgo1; Serologically defined breast cancer antigen NY-BR-85

Shugoshin Like Protein 1 (SGOL1)
CCC M220
HGNC 25088
MGI 1919665
PubMed 23850494
RGD 1593238
UniProt Q5FBB7
Wiki SGOL1
Endogenous HeLa cell SGOL1 was degraded by both CDC20- and CDH1-activated anaphase-promoting complex (APC), resulting in loss of SGOL1 from kinetochores during the metaphase-to-anaphase transition. SGOL1 depletion by RNA interference (RNAi) caused mitotic arrest with loss of sister kinetochore cohesion. Chromosomes and their centromeres did not align to form a metaphase plate; instead they scattered throughout the cell. SGOL1 depletion also destabilized kinetochore microtubules.
SGOL1 is required for mitotic progression and chromosome segregation and provides a link between sister centromere cohesion and microtubule interactions at kinetochores.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Shugoshin Like Protein 1 (SGOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Shugoshin Like Protein 1 (SGOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Shugoshin Like Protein 1 (SGOL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Shugoshin Like Protein 1 (SGOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Shugoshin Like Protein 1 (SGOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Shugoshin Like Protein 1 (SGOL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Shugoshin Like Protein 1 (SGOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Shugoshin Like Protein 1 (SGOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Shugoshin Like Protein 1 (SGOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Shugoshin Like Protein 1 (SGOL1) ELISA Kit Customized Service Offer
  1. "Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells."PLoS Biol. 3:433-449(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization."Curr. Biol. 15:353-359(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis."Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics."Cell Cycle 5:635-640(2006) [PubMed] [Europe PMC] [Abstract]
  7. "PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation."Dev. Cell 10:575-585(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1."Cell Cycle 6:1579-1585(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis."Cell Res. 17:608-618(2007) [PubMed] [Europe PMC] [Abstract]
  11. "sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1."Dev. Cell 14:331-341(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1."J. Biol. Chem. 284:1772-1780(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm." Nat. Genet. 46:1245-1249(2014) [PubMed] [Europe PMC] [Abstract]