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SET Domain And Mariner Transposase Fusion Gene (SETMAR)

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METNASE; Histone-lysine N-methyltransferase SETMAR

SET Domain And Mariner Transposase Fusion Gene (SETMAR)
CCC M211
HGNC 10762
MGI 1921979
PubMed 21124928
RGD 1565882
UniProt Q53H47
Wiki SETMAR
The deduced 671-amino acid protein contains an N-terminal pre-SET domain, followed by a SET domain, a transposase domain, and an integrase domain. The transposase domain contains a DDE acidic motif that is conserved among retroviral integrases and transposases and is essential for DNA strand cleavage and end joining. Metnase shares 50% amino acid identity with planarian mariner-9 in the transposase domain.
PSO4 bound SETMAR and formed a stable complex with SETMAR on DNA, and that ionizing radiation induced complex formation. In human embryonic kidney cells treated with PSO4 small interfering RNA, SETMAR failed to localize on DNA double-strand breaks and to stimulate DNA end joining.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain And Mariner Transposase Fusion Gene (SETMAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain And Mariner Transposase Fusion Gene (SETMAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain And Mariner Transposase Fusion Gene (SETMAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain And Mariner Transposase Fusion Gene (SETMAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain And Mariner Transposase Fusion Gene (SETMAR) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair."Proc. Natl. Acad. Sci. U.S.A. 102:18075-18080(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Birth of a chimeric primate gene by capture of the transposase gene from a mobile element."Proc. Natl. Acad. Sci. U.S.A. 103:8101-8106(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome."Gene 205:203-217(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity."Biochemistry 46:11369-11376(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends."Mol. Cell. Biol. 27:4589-4600(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair."J. Biol. Chem. 283:9023-9030(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation."Nucleic Acids Res. 36:5822-5831(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Metnase promotes restart and repair of stalled and collapsed replication forks."Nucleic Acids Res. 38:5681-5691(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining."Proc. Natl. Acad. Sci. U.S.A. 108:540-545(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart."Oncogene 31:4245-4254(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart."J. Biol. Chem. 289:10930-10938(2014) [PubMed] [Europe PMC] [Abstract]
  19. "The crystal structure of transposase domain of human histone-lysine N-methyltransferase SETMAR."Submitted (AUG-2009) to the PDB data bank
  20. "Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase."Biochemistry 49:5705-5713(2010) [PubMed] [Europe PMC] [Abstract]