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Nucleolar Protein With MIF4G Domain 1 (NOM1)

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SGD1; C7orf3; Nucleolar MIF4G domain-containing protein 1

Nucleolar Protein With MIF4G Domain 1 (NOM1)
CCC M209
HGNC 13244
MGI 1861749
PubMed 17965019
UniProt Q5C9Z4
Wiki NOM1
Proteins that contain MIF4G and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases .
The deduced 860-amino acid protein contains an N-terminal basic region, followed by an acidic region, a central MIF4G domain, and a C-terminal MA3 domain. Northern blot analysis of human cell lines detected a predominant transcript of 6.3 kb. Fluorescence- and epitope-tagged NOM1 localized to the nucleolus in transfected human cells.NOM1 interacted with EIF4A1, EIF4A2, and EIF4A3 (DDX48). Coimmunoprecipitation experiments showed interaction between NOM1 and EIF4A1 in transfected human embryonic kidney cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein With MIF4G Domain 1 (NOM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein With MIF4G Domain 1 (NOM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein With MIF4G Domain 1 (NOM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein With MIF4G Domain 1 (NOM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein With MIF4G Domain 1 (NOM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein With MIF4G Domain 1 (NOM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein With MIF4G Domain 1 (NOM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein With MIF4G Domain 1 (NOM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein With MIF4G Domain 1 (NOM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein With MIF4G Domain 1 (NOM1) ELISA Kit Customized Service Offer
  1. "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."Gene 347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
  2. "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36."Genomics 57:342-351(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "NOM1 targets protein phosphatase I to the nucleolus."J. Biol. Chem. 283:398-404(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]