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Sel1 Suppressor Of Lin 12 Like Protein (SEL1L)

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IBD2; SEL1-LIKE

Sel1 Suppressor Of Lin 12 Like Protein (SEL1L)
CCC M196
HGNC 10717
MGI 1329016
PubMed 24453213
RGD 620147
UniProt Q9UBV2
Wiki SEL1L
SEL1L exhibited a tissue-specific pattern of expression: high levels of a single 7.5-kb transcript were detected only in the pancreas of healthy individuals, whereas low to undetectable levels were observed in other adult tissues and in some fetal tissues.17% of adenocarcinomas of the pancreas did not express SEL1L to a detectable level; however, no gross genomic alterations were apparent within a few hundred kb of the relevant region. SEL1L immunoprecipitated with a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the ER lumen to the cytosol. Other proteins associated with the dislocation complex included HRD1 (SYVN1), derlin-2 (DERL2), the ATPase p97 (VCP), PDI (P4HB), BIP (HSPA5), calnexin (CANX), AUP1, UBXD8 (FAF2), UBC6E (UBE2J1), and OS9 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sel1 Suppressor Of Lin 12 Like Protein (SEL1L) ELISA Kit Customized Service Offer
  1. "Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1."J. Hum. Genet. 44:330-336(1999) [PubMed] [Europe PMC] [Abstract]
  2. "SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers."Hum. Genet. 106:227-235(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane."Proc. Natl. Acad. Sci. U.S.A. 102:14296-14301(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP."J. Biol. Chem. 283:20914-20924(2008) [PubMed] [Europe PMC] [Abstract]
  7. "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."Nat. Cell Biol. 10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex."Mol. Cell 34:627-633(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A luminal flavoprotein in endoplasmic reticulum-associated degradation."Proc. Natl. Acad. Sci. U.S.A. 106:14831-14836(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]