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Scribbled Homolog (SCRIB)

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CRIB1; SCRB1; SCRIB1; Vartul; LAP4

Scribbled Homolog (SCRIB)
CCC M193
HGNC 30377
MGI 2145950
PubMed 24140112
RGD 1565055
UniProt Q14160
Wiki SCRIB
Deficiency in Scrib impairs many aspects of cell polarity and cell movement. Scrib belongs to a protein complex containing betaPIX, an exchange factor for Rac/Cdc42, and GIT1, a GTPase activating protein for ARF6 implicated in receptor recycling and exocytosis.
SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization.The nucleotide sequence contains a central GAG repeat that occurs 19 times within a 36-triplet stretch, creating a glutamine-rich region in the deduced 1,551-amino acid protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scribbled Homolog (SCRIB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scribbled Homolog (SCRIB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scribbled Homolog (SCRIB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scribbled Homolog (SCRIB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scribbled Homolog (SCRIB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scribbled Homolog (SCRIB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scribbled Homolog (SCRIB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scribbled Homolog (SCRIB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scribbled Homolog (SCRIB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scribbled Homolog (SCRIB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scribbled Homolog (SCRIB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scribbled Homolog (SCRIB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scribbled Homolog (SCRIB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scribbled Homolog (SCRIB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scribbled Homolog (SCRIB) ELISA Kit Customized Service Offer
  1. "The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus."BMC Cell Biol. 6:1-1(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Junctional recruitment of mammalian Scribble relies on E-cadherin engagement."Oncogene 24:4330-4339(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase."Mol. Cell. Biol. 20:8244-8253(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Mammalian Scribble forms a tight complex with the betaPIX exchange factor."Curr. Biol. 14:987-995(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway."EMBO J. 24:1364-1374(2005) [PubMed] [Europe PMC] [Abstract]
  11. "hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells."FEBS Lett. 579:3725-3730(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins."FEBS Lett. 579:5061-5068(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin."J. Cell Biol. 171:1061-1071(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells."Cancer Sci. 97:1217-1225(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli."Genes Cells 11:453-464(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma."Cell 135:865-878(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Scrib regulates PAK activity during the cell migration process."Hum. Mol. Genet. 17:3552-3565(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling."Oncogene 27:5988-6001(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling."Cell. Microbiol. 10:696-712(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  24. "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."FEBS Lett. 583:2326-2332(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells."Biochim. Biophys. Acta 1823:1058-1067(2012) [PubMed] [Europe PMC] [Abstract]
  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Solution structure of the first, second and fourth PDZ domain of human scribble (KIAA0147 protein)."Submitted (NOV-2005) to the PDB data bank
  33. "Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis."Hum. Mutat. 33:440-447(2012) [PubMed] [Europe PMC] [Abstract]