≡

SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1)

[Edit]

SCOD1

SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1)
CCC M191
HGNC 10603
MGI 106362
PubMed 17189203
RGD 1559538
UniProt O75880
Wiki SCO1
The sco1 protein is a constituent of the inner mitochondrial membrane and is thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.
The predicted 301-amino acid human protein shares 34% identity with yeast sco1. SCOD1 contains a mitochondrial leader peptide, a putative transmembrane domain, and a copper-binding domain. In vitro mitochondrial import and trypsin-protection assays demonstrated that the SCOD1 protein is targeted to mitochondria. Northern blot analysis revealed that SCOD1 is predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OXPHOS), including muscle, heart, and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 1 (SCO1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain."Genomics 54:494-504(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency."Biochem. Biophys. Res. Commun. 276:530-533(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis."Cell Metab. 5:9-20(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein."J. Biol. Chem. 280:15202-15211(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A hint for the function of human Sco1 from different structures."Proc. Natl. Acad. Sci. U.S.A. 103:8595-8600(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Cytochrome c oxidase deficiency."Am. J. Med. Genet. 106:46-52(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy."Am. J. Hum. Genet. 67:1104-1109(2000) [PubMed] [Europe PMC] [Abstract]