SCAN Domain Containing Protein 1 (SCAND1)

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins.

SCAND1 belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.The deduced protein contains a C-terminal SCAN-like domain followed by an arginine-rich region. It has several putative phosphorylation sites and 2 N-myristoylation sites.