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SAM And SH3 Domain Containing Protein 1 (SASH1)

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SH3D6A; PEPE1; Proline-glutamate repeat-containing protein

SAM And SH3 Domain Containing Protein 1 (SASH1)
CCC M188
HGNC 19182
MGI 1917347
PubMed 23333244
UniProt O94885
Wiki SASH1
The deduced 1,247-amino acid protein has a calculated molecular mass of about 140 kD. SASH1 contains 2 sterile alpha modules (SAMs) and an Src homology-3 (SH3) domain. These domains are predominantly found in signaling molecules, adaptors, and scaffold proteins.
SASH1 also has an N-terminal 25-residue proline-rich sequence. The mRNA has a long 3-prime untranslated region that has 2 polyadenylation signals. The human and mouse SASH1 proteins share 85% homology. Northern blot analysis detected a 4.4-kb transcript that was expressed ubiquitously, with highest levels in lung, placenta, spleen, and thymus. A 7.5-kb transcript was detected at lower levels in all tissues surveyed except brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAM And SH3 Domain Containing Protein 1 (SASH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAM And SH3 Domain Containing Protein 1 (SASH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAM And SH3 Domain Containing Protein 1 (SASH1) Polyclonal Antibody Customized Service Offer
Assay Kits SEM188Hu ELISA Kit for SAM And SH3 Domain Containing Protein 1 (SASH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAM And SH3 Domain Containing Protein 1 (SASH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAM And SH3 Domain Containing Protein 1 (SASH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAM And SH3 Domain Containing Protein 1 (SASH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAM And SH3 Domain Containing Protein 1 (SASH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAM And SH3 Domain Containing Protein 1 (SASH1) ELISA Kit Customized Service Offer
  1. "SASH1 - a candidate tumour suppressor gene on chromosome 6q24.3 is downregulated in breast cancer."Oncogene 22:2972-2983(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the SH3 and SAM-domains from human SAM and SH3 domain-containing protein 1."Submitted (AUG-2007) to the PDB data bank