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SAM Domain And HD Domain Containing Protein 1 (SAMHD1)

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DCIP; HDDC1; MOP-5; SBBI88; AGS5; Monocyte Protein 5; Aicardi-Goutieres Syndrome 5; Dendritic cell-derived IFNG-induced protein

SAM Domain And HD Domain Containing Protein 1 (SAMHD1)
CCC M183
HGNC 15925
MGI 1927468
PubMed 24335234
RGD 1308369
UniProt Q9Y3Z3
Wiki SAMHD1
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) able to induce a primary T-cell response in vivo. With maturation, DCs shift from antigen-uptake and -processing functions to an antigen-presentation phenotype.
The deduced 626-amino acid protein, which is 72% identical to mouse Mg11, contains several phosphorylation and N-myristoylation sites, an N-glycosylation site, and an amidation site. It has no signal peptide or transmembrane region, suggesting that DCIP is an intracellular protein. RT-PCR analysis detected wide but variable expression in most cell lines tested. Northern blot analysis revealed expression of a 5.2-kb transcript in all tissues tested except brain and thymus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAM Domain And HD Domain Containing Protein 1 (SAMHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAM Domain And HD Domain Containing Protein 1 (SAMHD1) ELISA Kit Customized Service Offer
  1. "Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells."Immunol. Lett. 74:221-224(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAY-2006) to UniProtKB
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts."Proteomics 8:2640-2650(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutieres syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression."Hum. Mutat. 31:E1836-E1850(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Identification and characterization of naturally occurring splice variants of SAMHD1."Retrovirology 9:86-86(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the N-terminal SAM-domain of the SAM domain and HD domain containing protein 1 (dendritic cell-derived IFNG-induced protein) (DCIP) (monocyte protein 5) (MOP-5)."Submitted (JUL-2007) to the PDB data bank
  19. "HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase."Nature 480:379-382(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase."Nat. Commun. 4:2722-2722(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Mechanism of allosteric activation of SAMHD1 by dGTP."Nat. Struct. Mol. Biol. 20:1304-1309(2013) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis of lentiviral subversion of a cellular protein degradation pathway."Nature 505:234-238(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response." Nat. Genet. 41:829-832(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome." Arthritis Rheum. 62:1469-1477(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus."Am. J. Med. Genet. A 155:235-237(2011) [PubMed] [Europe PMC] [Abstract]