≡

Sterile Alpha Motif Domain Containing Protein 9 (SaMD9)

[Edit]

NFTC; OEF1; OEF2; C7orf5

Sterile Alpha Motif Domain Containing Protein 9 (SaMD9)
CCC M180
HGNC 1348
PubMed 16960814
UniProt Q5K651
Wiki SAMD9
SAMD9 encodes a 1,589-amino acid protein that is expressed in a wide range of tissues, including skin. Quantitative real-time PCR showed that the gene is strongly expressed in endothelial cells and, to a lesser degree, in fibroblasts.
SAMD9 was one of the most differentially regulated genes in an aggressive fibromatosis tumor with inactivation of the APC gene compared with the same cells after transfection of wildtype APC. Knockdown of SAMD9 by RNA interference increased the proliferation and invasiveness of a normal lung fibroblast cell line, whereas SAMD9 overexpression reduced cell proliferation and motility, and increased apoptosis in a colon cancer cell line. SAMD9 overexpression reduced tumor volume following transplantation in immune-deficient mice.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterile Alpha Motif Domain Containing Protein 9 (SaMD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterile Alpha Motif Domain Containing Protein 9 (SaMD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterile Alpha Motif Domain Containing Protein 9 (SaMD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterile Alpha Motif Domain Containing Protein 9 (SaMD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterile Alpha Motif Domain Containing Protein 9 (SaMD9) ELISA Kit Customized Service Offer
  1. "Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse."BMC Genomics 8:92-92(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive protein."J. Invest. Dermatol. 128:1423-1429(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis."Am. J. Hum. Genet. 79:759-764(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis."J. Invest. Dermatol. 131:662-669(2011) [PubMed] [Europe PMC] [Abstract]