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R-Spondin 2 (RSPO2)

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Roof plate-specific spondin-2

R-Spondin 2 (RSPO2)
CCC M172
HGNC 28583
MGI 1922667
PubMed 22895193
RGD 1562331
UniProt Q6UXX9
Wiki RSPO2
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1) signaling. Xenopus and human RSPO2 enhanced mouse Wnt3a signaling in transfected human embryonic kidney cells. C-terminally truncated Xenopus Rspo2, but not the full-length protein, was secreted from cells and retained its activity. Mutation analysis showed that the TSP1 domain of Xenopus Rspo2 was dispensable for activity, but the furin domains were required. RT-PCR analysis showed that Xenopus embryos injected with Wnt8 or beta-catenin induced Rspo2 and Rspo3. Overexpression of Rspo2 in Xenopus activated the Wnt/beta-catenin pathway upstream of dishevelled (DVL1), interfered with Tgfb-type growth factors, and promoted myogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant R-Spondin 2 (RSPO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to R-Spondin 2 (RSPO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to R-Spondin 2 (RSPO2) Polyclonal Antibody Customized Service Offer
Assay Kits SEM172Hu ELISA Kit for R-Spondin 2 (RSPO2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant R-Spondin 2 (RSPO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to R-Spondin 2 (RSPO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to R-Spondin 2 (RSPO2) Polyclonal Antibody Customized Service Offer
Assay Kits SEM172Mu ELISA Kit for R-Spondin 2 (RSPO2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant R-Spondin 2 (RSPO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to R-Spondin 2 (RSPO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to R-Spondin 2 (RSPO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for R-Spondin 2 (RSPO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for R-Spondin 2 (RSPO2) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "R-spondin proteins: a novel link to beta-catenin activation."Cell Cycle 5:23-26(2006) [PubMed] [Europe PMC] [Abstract]
  6. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]
  8. "LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."PLoS ONE 7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]