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Ras Related GTP Binding Protein D (RRAGD)

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Ras Related GTP Binding Protein D (RRAGD)
CCC M165
HGNC 19903
MGI 1098604
PubMed 14660641
RGD 1310007
UniProt Q9NQL2
RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.
The deduced 400-amino acid protein contains 3 phosphate/magnesium-binding motifs, 3 guanine nucleotide-binding motifs, and a C-terminal leucine zipper and coiled-coil structure. RRAGD and RRAGC share 81% amino acid homology, including 90% identity in their central portions; the N and C termini are less conserved.RRAGD and RRAGA interact through their C termini. RRAGD associated with both the GDP- and GTP-bound forms of RRAGA, and the subcellular localization of RRAGD depended on the nucleotide-bound state of RRAGA and its localization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein D (RRAGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein D (RRAGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein D (RRAGD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein D (RRAGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein D (RRAGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein D (RRAGD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein D (RRAGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein D (RRAGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein D (RRAGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein D (RRAGD) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  6. "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D."J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1."Science 320:1496-1501(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."Cell 141:290-303(2010) [PubMed] [Europe PMC] [Abstract]
  9. "SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling."Mol. Cell 46:833-846(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human Ras-related GTP-binding D."Submitted (FEB-2009) to the PDB data bank
  11. "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1."Nature 519:477-481(2015) [PubMed] [Europe PMC] [Abstract]
  12. "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1."Science 347:188-194(2015) [PubMed] [Europe PMC] [Abstract]