Rabphilin 3A Like Protein (RPH3AL)

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NOC2; No C2 domains protein; Rab effector Noc2

Rabphilin 3A Like Protein (RPH3AL)
Noc2 interacts with the LIM domain-containing protein zyxin, a component of the cytoskeleton. A partial rabphilin-3A-related protein was identified and designated Noc2; a full-length Noc2 clone was isolated from a rat insulin-secreting cell line cDNA library. The Noc2 cDNA encodes a 302-amino acid protein that shows 40.7% amino acid identity and 77.9% similarity to the N-terminal region of rat rabphilin-3A. However, it lacks the C2 domains, and hence the Noc2 designation. Noc2 contains 1 potential protein kinase A and 3 potential protein kinase C phosphorylation sites. RNA blot analysis revealed that a single 2.2- or 2.6-kb transcript of Noc2 is expressed at very high levels in pancreatic islets, and at low to moderate or high levels in other endocrine tissues and hormone-secreting cell lines, but at very low levels in brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabphilin 3A Like Protein (RPH3AL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabphilin 3A Like Protein (RPH3AL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabphilin 3A Like Protein (RPH3AL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabphilin 3A Like Protein (RPH3AL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabphilin 3A Like Protein (RPH3AL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabphilin 3A Like Protein (RPH3AL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabphilin 3A Like Protein (RPH3AL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabphilin 3A Like Protein (RPH3AL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabphilin 3A Like Protein (RPH3AL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabphilin 3A Like Protein (RPH3AL) ELISA Kit Customized Service Offer
  1. "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus."Genomics 59:97-101(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells."Biochem. Biophys. Res. Commun. 316:218-225(2004) [PubMed] [Europe PMC] [Abstract]