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RNA Methyltransferase Like Protein 1 (RNMTL1)

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HC90; MRM3; 16S rRNA (guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; rRNA methyltransferase 3, mitochondrial

RNA Methyltransferase Like Protein 1 (RNMTL1)
CCC M153
HGNC 18485
MGI 1914640
PubMed 12296377
UniProt Q9HC36
Wiki RNMTL1
RNMTL1 shares 32 to 42% amino acid identity with S. cerevisiae Pet56 and E. coli RNA methyltransferases, especially over the region implicated in transfer of the methyl group to rRNA. RT-PCR analysis showed no difference in expression between human hepatocellular carcinoma and normal liver cell lines or tissues.
Transfection of deletion mutants, followed by luciferase reporter assay, identified a minimal promoter element at -71 to +1 of the RNMTL1 sequence. Database analysis, followed by mobility shift assay, determined that the RNMTL1 promoter is bound by ATF/CREB, E2F-DP/SP1, and other transcription factors. YY1 acts as a negative regulator of RNMTL1 transcription via a proposed interaction with ATF/CREB.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Methyltransferase Like Protein 1 (RNMTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Methyltransferase Like Protein 1 (RNMTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Methyltransferase Like Protein 1 (RNMTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Methyltransferase Like Protein 1 (RNMTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Methyltransferase Like Protein 1 (RNMTL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Methyltransferase Like Protein 1 (RNMTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Methyltransferase Like Protein 1 (RNMTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Methyltransferase Like Protein 1 (RNMTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Methyltransferase Like Protein 1 (RNMTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Methyltransferase Like Protein 1 (RNMTL1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene."Cell Res. 12:177-197(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid."J. Biol. Chem. 288:31386-31399(2013) [PubMed] [Europe PMC] [Abstract]
  6. "Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA."J. Biol. Chem. 289:24936-24942(2014) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome."Mol. Biol. Cell 25:2542-2555(2014) [PubMed] [Europe PMC] [Abstract]