Repulsive Guidance Molecule B (RGMB)

[Edit]

DRAGON; DRG11-responsive axonal guidance and outgrowth of neurite

Repulsive Guidance Molecule B (RGMB)
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family and contributes to the patterning of the developing nervous system.The deduced 436-amino acid mouse Rgmb protein is predicted to be a GPI-anchor protein with an N-terminal signal peptide and C-terminal hydrophobic domain. Rgmb shares 50 to 60% homology with Rgma and hemojuvelin.
Rgmb expression was detected primarily in fetal mouse DRG, dorsomedial mantle layer of the spinal cord, alar plate of the myelencephalon, marginal layer of the mesencephalon, basal plate of the pons, and cerebellar primordia, as well as the cortex of the olfactory lobe, retina, and olfactory epithelium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Repulsive Guidance Molecule B (RGMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Repulsive Guidance Molecule B (RGMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Repulsive Guidance Molecule B (RGMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Repulsive Guidance Molecule B (RGMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Repulsive Guidance Molecule B (RGMB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Repulsive Guidance Molecule B (RGMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Repulsive Guidance Molecule B (RGMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Repulsive Guidance Molecule B (RGMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Repulsive Guidance Molecule B (RGMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Repulsive Guidance Molecule B (RGMB) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury."Biochem. Biophys. Res. Commun. 382:795-800(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub."Science 341:77-80(2013) [PubMed] [Europe PMC] [Abstract]