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Rififylin (RFFL)

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RNF189; RNF34L; Fring; Ring Finger And FYVE-Like Domain Containing 1; E3 ubiquitin-protein ligase rififylin; Caspases-8 and -10-associated RING finger protein 2

Rififylin (RFFL)
CCC M136
HGNC 24821
MGI 1914588
PubMed 15229288
RGD 727916
UniProt Q8WZ73
Wiki RFFL
The mouse Rffl cDNA encodes 2 proteins of 336 and 364 amino acids, generated by alternative splicing. The N-terminal region contains a domain related to the FYVE double zinc finger domain that mediates binding to phosphatidylinositol 3-phosphate (PIK3), and the C-terminal region contains a consensus sequence for a C3HC4 RING finger domain.
Northern blot analysis revealed a ubiquitously expressed transcript of approximately 4 kb and a smaller transcript of about 2 kb at a very high level in testis and at a moderate level in liver. RT-PCR indicated that both proteins are ubiquitously expressed, with the larger isoform almost exclusively expressed in adult mouse liver and kidney cells and in HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rififylin (RFFL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rififylin (RFFL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rififylin (RFFL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rififylin (RFFL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rififylin (RFFL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rififylin (RFFL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rififylin (RFFL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rififylin (RFFL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rififylin (RFFL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rififylin (RFFL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rififylin (RFFL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rififylin (RFFL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rififylin (RFFL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rififylin (RFFL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rififylin (RFFL) ELISA Kit Customized Service Offer
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  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2."Structure 12:2257-2263(2004) [PubMed] [Europe PMC] [Abstract]