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RecQ Protein Like Protein 5 (RECQL5)

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RECQ5; ATP-Dependent DNA Helicase Q5; DNA helicase, RecQ-like type 5

RecQ Protein Like Protein 5 (RECQL5)
CCC M123
HGNC 9950
MGI 2156841
PubMed 22013166
RGD 1310823
UniProt O94762
Wiki RECQL5
RECQL5 encodes a protein of 410 amino acids. The RECQL5 helicase has a small molecular weight of 46 kD, similar to that of the human RECQ1 helicase. Both RECQL4 and RECQL5 have helicase domains that contain 7 consensus motifs in the middle of the molecules. Northern blot analysis detected RECQL5 expression in almost all tissues tested, with notably strong expression in pancreas and testis. RECQ1 has a similar expression profile.human RECQL5 bound the recombinase RAD51 and inhibited RAD51-mediated D-loop formation. Biochemical assays and electron microscopy showed that RECQL5 displaced RAD51 from single-stranded DNA (ssDNA) in a reaction that required ATP hydrolysis and the ssDNA-binding protein RPA (RPA1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Protein Like Protein 5 (RECQL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Protein Like Protein 5 (RECQL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Protein Like Protein 5 (RECQL5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Protein Like Protein 5 (RECQL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Protein Like Protein 5 (RECQL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Protein Like Protein 5 (RECQL5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Protein Like Protein 5 (RECQL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Protein Like Protein 5 (RECQL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Protein Like Protein 5 (RECQL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Protein Like Protein 5 (RECQL5) ELISA Kit Customized Service Offer
  1. "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes."Genomics 54:443-452(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing."Nucleic Acids Res. 27:3762-3769(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human RecQ5-beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3-alpha and 3-beta."Nucleic Acids Res. 28:1647-1655(2000) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Human RECQL5 overcomes thymidine-induced replication stress."DNA Repair 9:964-975(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity."J. Biol. Chem. 285:15739-15745(2010) [PubMed] [Europe PMC] [Abstract]
  10. "RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase."Mol. Cell. Biol. 30:2460-2472(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Human RECQL5 participates in the removal of endogenous DNA damage."Mol. Biol. Cell 23:4273-4285(2012) [PubMed] [Europe PMC] [Abstract]
  12. "RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression."Nucleic Acids Res. 40:1621-1635(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair."Carcinogenesis 34:2218-2230(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5."Nat. Struct. Mol. Biol. 20:892-899(2013) [PubMed] [Europe PMC] [Abstract]